The emblem of Andhra Medical College was designed by Dr F. J. Anderson, the first Principal of the College. The signs used in the emblem are significant. Here's how it goes: the deep blue background of the emblem reflects the serene Bay of Bengal on whose shores the Andhra Medical College stands. It suggests the depth of the knowledge imparted by the college. The 'red cross' is the accepted sign of ambulance service and stands for the motto of the medical profession viz. providing medical service to the suffering.

The 'trident' (Trisoolam) is a sceptre of power held by Neptune, the Lord of the seas. It is the invocation to the Lord of the seas to guard the great Andhra Medical College.

The 'serpent' in the emblem stands for knowledge and wisdom. The serpent winding around the trident signifies that the power of the College arises out of knowledge and wisdom.